MBP Interacts with PIP2 at the Oligodendroglial Cell Membrane: The Role of Phosphoinositides in the Interaction of Myelin Basic ,Used

MBP Interacts with PIP2 at the Oligodendroglial Cell Membrane: The Role of Phosphoinositides in the Interaction of Myelin Basic ,Used

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The only protein known to be essential for myelin formation and compaction in the central nervous system is myelin basic protein (MBP). The association of MBP as a positivelycharged protein with negatively charged membranes is crucial for myelination, but the mechanisms by which MBP associates with the myelin membrane remains elusive. Here I demonstrate that the signaling lipid PIP2 is important for the stable association of MBP with cellular membranes. This association is lost upon specific decrease of membrane charges through selective hydrolyzation of PIP2 levels or through elevated intracellular Ca2+ levels. Further experiments implicate that one putative PIP2 binding domain of MBP lies within the exon1 encoded region. The relevance of this proteinlipid interaction was demonstrated for the corpus callosum of mice, after decreasing membrane surface charges in acute brain slices. Here, PIP2 hydrolysis led to the loss of myelin compaction. The results demonstrate that PIP2 plays an important role in MBP association to the plasma membrane. These findings provide a novel link between phosphoinositol metabolism and MBP function in oligodendrocytes in development and disease.

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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.

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To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.

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Warranty

We provide a 2-year limited warranty, from the date of purchase for all our products.

If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.

This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).

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