Mechanisms Of Lymphocyte Activation And Immune Regulation Viii: Autoimmunity 2000 And Beyond (Advances In Experimental Medicine ,Used

Mechanisms Of Lymphocyte Activation And Immune Regulation Viii: Autoimmunity 2000 And Beyond (Advances In Experimental Medicine ,Used

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Advances in biochemistry, cell biology, genomewide mutagenesis coupled with molecular technology, including gene microarray and transgenic and knockout animals have been instrumental in understanding the cellular processes and molecular pathways of selftolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain autoimmune diseases that are based on the pathogenesis of diseases rather than on broadspectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of autoimmune diseases and designing novel therapy. This book covers three major areas of autoimmunity: the basic mechanisms of immunological tolerance, pathogenesis of autoimmune diseases, and some novel therapies.This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.

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