Medicinal Chemistry: A Molecular And Biochemical Approach

Medicinal Chemistry: A Molecular And Biochemical Approach

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Fully Updated And Rewritten By A Basic Scientist Who Is Also A Practicing Physician, The Third Edition Of This Popular Textbook Remains Comprehensive, Authoritative And Readable. Taking A Receptorbased, Targetcentered Approach, It Presents The Concepts Central To The Study Of Drug Action In A Logical, Mechanistic Way Grounded On Molecular And Biochemical Principles. Students Of Pharmacy, Chemistry And Pharmacology, As Well As Researchers Interested In A Better Understanding Of Drug Design, Will Find This Book An Invaluable Resource.Starting With An Overview Of Basic Principles, Medicinal Chemistry Examines The Properties Of Drug Molecules, The Characteristics Of Drug Receptors, And The Nature Of Drugreceptor Interactions. Then It Systematically Examines The Various Families Of Receptors Involved In Human Disease And Drug Design. The First Three Classes Of Receptors Are Related To Endogenous Molecules: Neurotransmitters, Hormones And Immunomodulators. Next, Receptors Associated With Cellular Organelles (Mitochondria, Cell Nucleus), Endogenous Macromolecules (Membrane Proteins, Cytoplasmic Enzymes) And Exogenous Pathogens (Viruses, Bacteria) Are Examined. Through This Evaluation Of Receptors, All The Main Types Of Human Disease And All Major Categories Of Drugs Are Considered.There Have Been Many Changes In The Third Edition, Including A New Chapter On The Immune System. Because Of Their Increasingly Prominent Role In Drug Discovery, Molecular Modeling Techniques, High Throughput Screening, Neuropharmacology And Genetics/Genomics Are Given Much More Attention. The Chapter On Hormonal Therapies Has Been Thoroughly Updated And Reorganized. Emerging Enzyme Targets In Drug Design (E.G. Kinases, Caspases) Are Discussed, And Recent Information On Voltagegated And Ligandgated Ion Channels Has Been Incorporated. The Sections On Antihypertensive, Antiviral, Antibacterial, Antiinflammatory, Antiarrhythmic, And Anticancer Drugs, As Well As Treatments For Hyperlipidemia And Peptic Ulcer, Have Been Substantially Expanded. One New Feature Will Enhance The Book'S Appeal To All Readers: Clinicalmolecular Interface Sections That Facilitate Understanding Of The Treatment Of Human Disease At A Molecular Level.

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Frequently Asked Questions

  • Q: What is the main focus of 'Medicinal Chemistry: A Molecular and Biochemical Approach'? A: The book focuses on a receptor-based, target-centered approach to studying drug action, emphasizing molecular and biochemical principles.
  • Q: Who is the author of this textbook and what is their background? A: The author is Thomas Nogrady, a basic scientist and practicing physician, ensuring a comprehensive and authoritative perspective on medicinal chemistry.
  • Q: How many pages does the book have? A: The textbook contains 672 pages, providing extensive coverage of medicinal chemistry topics.
  • Q: What are the key topics covered in the third edition? A: Key topics include drug properties, drug-receptor interactions, families of receptors, and various classes of drugs related to human disease.
  • Q: Is there any new content in the third edition compared to previous editions? A: Yes, the third edition includes a new chapter on the immune system and expanded discussions on molecular modeling, high throughput screening, and recent drug therapies.
  • Q: What type of readers would benefit from this book? A: Students of pharmacy, chemistry, pharmacology, and researchers interested in drug design will find this book invaluable.
  • Q: What is the binding type of this edition? A: This edition is available in paperback binding, making it accessible for students and professionals.
  • Q: When was the third edition published? A: The third edition of 'Medicinal Chemistry: A Molecular and Biochemical Approach' was published on August 11, 2005.
  • Q: Does the book cover modern therapeutic approaches? A: Yes, it discusses emerging enzyme targets in drug design, including kinases and caspases, and updates on various drug categories like antiviral and anticancer drugs.
  • Q: What makes this textbook different from other medicinal chemistry books? A: Its comprehensive, logical approach and integration of clinical-molecular interface sections enhance understanding of disease treatment at a molecular level.