Title
Mesenchymal Stem Cell Aging: Implications for Cellular Cardiomyoplasty: A Theoretical Exposition,Used
Delivery time: 8-12 business days (International)
Cellbased therapy geared at the replacement of lost myocardial cells, and subsequent regeneration of damaged myocardial tissue is a viable and attractive therapeutic option. Bone Marrow derived Mesenchymal stem cells (BMMSCs) have emerged in recent years as a practical and clinically relevant stem cell for the technique of cellular cardiomyoplasty. Enthusiasm for BMMSCs is however tempered by evidence that cells from older donors show measurable and qualitative changes in their efficacy. This work provides a theoretical exposition on why BMMSCs are a preferred cell source for cardiac regeneration, outlines aspects of their appeal that is diminished by natural aging, and discusses approaches to their in vitro cardiomyogenic differentiation. Also presented is a theoretical discussion of the physiological significance of nuclear cardiac troponins and tropomyosin with regard to BMMSC specific cardiomyogenesis, the importance of the stem cell niche environment, and its potential contribution to diminished BMMSC plasticity with advancing age.
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⚠️ WARNING (California Proposition 65):
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For more information, please visit www.P65Warnings.ca.gov.
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Shipping & Returns
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
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Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.