Title
Modeling diffusion controlled reactions in living cells: A solution to the subdiffusionefficiency paradox of EcoRV enzyme in E.,Used
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Macromolecular crowding in living biological cells effects subdiffusion of larger biomolecules such as proteins and enzymes. Mimicking this subdiffusion in terms of random walks on a critical percolation cluster, fractional Brownian motion and continuous time random walk, we here present a case study of EcoRV restriction enzymes involved in vital cellular defence. EcoRV has been found in two configurational states. We show that due to its so far elusive propensity to an inactive state the enzyme avoids nonspecific binding and remains welldistributed in the bulk cytoplasm of the cell. Despite the reduced volume exploration of subdiffusion processes, the low activity of the enzyme surprisingly guarantees a high efficiency of the enzyme. Our results corroborate a more local picture of cellular regulation and demonstrated a solution to subdiffusionefficiency paradox; Specific molecular design renders the efficiency of EcoRV enzymes almost independent on the exact diffusion conditions. This case study also provides us a chance to compare different subdiffusive processes in living cells and guides us to a broader understating of diffusion controlled reactions in living cells.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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