Title
Molecular mechanisms of T cell tolerance: Regualtion of FOXP3 expression: a key transcription factor for regulatory T cells,Used
Delivery time: 8-12 business days (International)
Regulatory T cells (Tregs) play an important role in immune homeostasis, by maintaining tolerance to selfantigens and allergens as well as by limiting inflammatory tissue damage during chronic infections. Humans or mice lacking the Tregassociated transcription factor FOXP3 develop severe features of autoimmunity and allergy. Ectopic FOXP3 expression endows nonregulatory T cells with many of the hallmarks of regulatory T cells and transgenic reporter mice carrying a FOXP3GFP indicated that FOXP3 expression correlates with suppressive T cells. Although Tregs can be generated in the thymus, their induction is observed in the periphery. The molecular mechanisms leading to Tregs generation in the periphery are still poorly understood. To gain insight into this key process we analyzed peripheral FOXP3 regulation. For this purpose we localized and cloned the human FOXP3 promoter into a reporter plasmid and characterized its activity in primary CD4+ T cells. In addition, we looked at factors, which regulate FOXP3 expression during the differentiation process from nave T cells into the effectors cells.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.