Title
Molecular Regulation of the Exocytic Mode in Adrenal Chromaffin Cells: The Role of MARCKS and Non Muscle Myosin II in the Regula,Used
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Neuroendocrine chromaffin cells of the adrenal medulla are a primary output for the sympathetic nervous system. Chromaffin cells release catecholamine as well as vaso and neuroactive peptide transmitters into the circulation through exocytic fusion of large densecore secretory granules. Under basal sympathetic firing, chromaffin cells selectively release modest levels of catecholamines, helping to set the ?rest and digest? status of energy storage. Under stress activation, elevated sympathetic firing leads to increased catecholamine as well as peptide transmitter release to set the ?fight or flight? status of energy expenditure. While the mechanism for catecholamine release is widely studied, relatively little is known of how peptide transmitter release is regulated to occur selectively under elevated stimulation. This work investigated the role cytoskeletal elements and molecular motors play in the regulation of transmitter release from chromaffin cells. In summary, an intact actin cortex is required for modest release of catecholamines, while dissolution of the actin cortex and concomitant activation of mysoin II results in the increased transmitter release.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
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