Nanostrukturirovannye formy protivoopukholevykh preparatov: Liposomy Lizomustina i BKhNM. Khimikofarmatsevticheskiy analiz. Pro,Used

Nanostrukturirovannye formy protivoopukholevykh preparatov: Liposomy Lizomustina i BKhNM. Khimikofarmatsevticheskiy analiz. Pro,Used

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Brand: LAP Lambert Academic Publishing
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Sozdany i eksperimental'no obosnovany sostavy stericheski stabilizirovannykh liposom Lizomustina i BKhNM s distearoilfosfotidiletanolaminpolietilenglikolem5000 v lipidnom bisloe, obladayushchie bol'shey, chem sushchestvuyushchie lekarstvennye formy izbiratel'nost'yu protivoopukholevogo deystviya. Razrabotany emul'sionnoekstruzionnye tekhnologii polucheniya liposom Lizomustina i BKhNM. Ustanovleny kriterii i metody otsenki kachestva liposomal'nykh lekarstvennykh form Lizomustina i BKhNM, opredeleny parametry ikh standartnosti. Pokazana vozmozhnost' stabilizatsii liposomal'noy dispersii Lizomustina metodom sublimatsionnoy sushki. Ustanovlen rezhim zamorazhivaniya i sushki, pozvolyayushchiy poluchat' lekarstvennuyu formu Lizomustin liposomal'nyy liofilizat dlya prigotovleniya rastvora dlya in"ektsiy 20 mg, sootvetstvuyushchuyu proektu FSP. Otseneno vliyanie vsekh stadiy tekhnologicheskogo protsessa na konechnyy produkt. Pokazano, chto na eksperimental'nykh modelyakh opukholey zhivotnykh limfoblastnom leykoze i kartsinome legkogo L'yuis nanostrukturirovannaya lekarstvennaya forma Lizomustina povyshaet biodostupnost', rasshiryaet diapazon terapevticheskikh doz bez proyavleniya toksichnosti.

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