Title
Neuropharmacology of Polyamines (Neuroscience Perspectives),Used
Delivery time: 8-12 business days (International)
Polyamines have had a hard time competing for research interest. As anyone who has studied polyamines knows, it is possible to observe some sort of polyamine effect in almost any assay system at high concentrations, and their generality of action has obviously been a deterrent to intensive research. Most of the research is concentrated in the field of cancer and relatively little polyamine research is neuroscience related, although in 1926 spermine (then known as neuridinc) was first isolated from brain tissue. Further research revealed the existence of uptake and release mechanisms for brain polyamines, as seen with other substances more commonly accepted as neurotransmitters. Polyamines were also found to play a regulatory role in cellular calcium homeostasis and to have a metabolism that is deregulated in response to cerebral trauma or ischaemia, and finally to modulate the NMDA receptor. It was this last effect which tipped the balance in favour of intensive research into polyamines in the brain.Despite their ubiquity and demonstrated links with many important physiological regulatory processes, there is no coherent hypothesis to explain their presence or role in cellular physiology. This book does not provide such a hypothesis, but attempts togroup the known effects and properties of polyamines as applied to neuroscience and to stimulate interest in this field. The polyamines are deliberately treated as neuromodulators or neurotransmitters with an important and specific function in the brain. This assumption is far from proven, but it is hoped that enough interest in this research area will be stimulated which will result in a more precise definition of polyamine function in the future.
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For more information, please visit www.P65Warnings.ca.gov.
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Shipping & Returns
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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