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The rapidly developing field of systems biology is influencing many aspects of biological research and is expected to transform biomedicine. Some emerging offshoots and specialized branches in systems biology are receiving particular attention and are becoming highly active areas of research. This collection of invited reviews describes some of the latest cuttingedge experimental and computational advances in these emerging subfields of systems biology. In particular, this collection focuses on the study of mammalian embryonic stem cells; new technologies involving massspectrometry proteomics; single cell measurements; methods for modeling complex stochastic systems; networkbased classification algorithms; and the revolutionary emerging field of systems pharmacology.
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