NFkB , A Network Hub Controlling Immunity, Inflammation, and Cancer (Cold Spring Harbor Perspectives in Biology),Used

NFkB , A Network Hub Controlling Immunity, Inflammation, and Cancer (Cold Spring Harbor Perspectives in Biology),Used

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NFkB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NFkB, its DNAbinding activity and specificity, the role of the inhibitor I?B, and canonical and alternative mechanisms of NFkB activation. The contributors examine the physiological role of NFkB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NFkB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NFkB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NFkB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.

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