Title
NMR Studies of Structural Motifs: Protein Folding and Ligand Binding,Used
Delivery time: 8-12 business days (International)
NMR of Structural Motifs: The agrin G3 domain is critical in development and maintenance of the neuromuscular junction. G3 binds ?dystroglycan and initiates acetylcholine receptor clustering on myotube membranes. Using NMR spectroscopy, we show both active B8 and inactive B0 isoforms binding sialic acid, heparin, and heparan sulfate and map the binding sites. Ligand dissociation constants were determined by isothermal titration calorimetry. Pulse field gradient diffusion NMR was used to determine heparin binding stoichiometry, 2 protein per heparin. Residual dipolar couplings (RDCs) were used to probe residual denatured OBfold protein structure; folded staphylococcal nuclease (SN) has greater RDC differences. Invariance of denatured SN RDCs had been attributed to robustness of longrange denatured state structure. We show, however, that increased RDC differences in the folded states are a consequence of close packing of native state polypeptide, more consistent with disruption of cooperative structure in folded states than with retention of denatured longrange fold topology. RDCs were used to locate residual secondary structure in denatured OBfold LysN and CspA ?sheets.
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For more information, please visit www.P65Warnings.ca.gov.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
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