Title
Novel Drug Delivery Systems For GeneTargeted RNA Interference: Application of RNAi for Cancer Gene Therapy,Used
Delivery time: 8-12 business days (International)
RNA interference refers to sequencespecific messenger RNA degradation initiated by introduction of short RNA duplexes. Since this event results in targetspecific gene silencing, siRNAs are expected to serve as potential therapeutic agents to silence diseasecausing genes. However, a substantial barrier to the therapeutic application is the delivery of siRNA duplexes into cells. Cyanocobalamin is one of the essential vitamins needed for the division of all cells. Cancer cells especially require abnormally high amounts of cobalamins due to rapid cell division. As a result, the cobalamin receptor density on the surface of the cell is overexpressed. Therefore, a 21 nucleotide long bcrabl genespecific siRNA was conjugated to cyanocobalamin, and its uptake, genesilencing effect, and inhibition of cancer cell proliferation were investigated in K562 human chronic myelogenous leukemia cells. Results and findings discussed in this book indicate to open a door for the potential use of cobalamin as a novel carrier of siRNA for genetargeted RNA interference.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.