Title
Nuclear and cytoplasmic control of the DNA damage checkpoint: A new way of looking at cell cycle control,Used
Delivery time: 8-12 business days (International)
Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. It is well known that there are different checkpoints for different stresses a cell could face, one of them being the DNA damage checkpoint. For long the activity of this checkpoint was thought to be limited to the nucleus. In this and other emerging studies it has now been established that the DNA damage checkpoint can regulate cell cycle arrest, nuclear positioning and movement by controlling cytoplasmic factors and events. This study establishes a novel regulatory mechanism of the DNA damage checkpoint involving vesicular transport system and cytoplasmic, nonproteosomal protein degradation. The study also focuses on the connection between the spindle assembly checkpoint (SAC) and the DNA damage checkpoint. To study this we generate an acentric chromosome with a single DNA double strand break on it. We find that budding yeast cells that have one chromosome with conditional GAL1Cen centromere turned off cannot activate the SAC and both the sister chromatids of this chromosome get preferentially segregated to the mother cell.
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For more information, please visit www.P65Warnings.ca.gov.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.