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Nucleic Acids: Curvature And Deformation: Recent Advances And New Paradigms (Acs Symposium Series),Used
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Curvature and Deformation of Nucleic Acids: Recent Advances, New Paradigms presents an uptodate review on the curvature and deformation of nucleic acids. Chapter 1 sets the various chapters in context, as well as describing several controversial topics. Chapter 2 gives a comprehensivereview of the literature on DNA bending and describes the current status of molecular dynamics simulations of DNA and proteinDNA complexes. Chapter 3 describes the structural basis for Atract DNA helix bending, based on recent NMR structures and other biophysical measurements. Chapter 4 describesthe localization of Mg++ ions in the crystal structure of a Bform DNA dodecamer and discusses the relevance of these bound ions to sequencedependent bending. Chapter 5 discusses the electrostatic energy penalties that result from phosphate crowding in curved DNA oligomers. Chapter 6 presents aquantitative model that predicts the magnitude of the bend caused by asymmetric charge neutralization of DNA phosphate residues. Chapter 7 reviews the structural and dynamic properties of fourway DNA junctions in the presence of metal ions, and it describes the exchange between alternative stackingconformers in solution. Chapter 8 documents the fact that a conserved pseudouridine residue in an RNA duplex containing a precursor messenger branch site makes an important contribution to the structure of the molecule. Chapter 9 describes structural perturbations that are observed indiseaserelated mutants of human mitochondrial transfer RNAs. Chapter 10 reviews the thermodynamics of the folding and unfolding of DNA oligomers distorted by the binding of small ligands. Chapter 11 describes a method of constructing DNA fragments for cyclization studies that uses single strandgaps as flexible hinges that allow the correct torsional orientation of the helix ends. Chapter 12 reviews a statistical mechanical model that predicts the stability of reconstituted nucleosomes based on sequencedependent DNA curvature and flexibility.
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