Title
p50 NF?B and Dendritic Cells: a matter of life and death: The p50 subunit of NF?B orchestrates dendritic cell lifespan and act,Used
Delivery time: 8-12 business days (International)
Already 10 years ago, p50, a regulatory subunit of the NF?B family of transcription factors was shown to accumulate in the nucleus of LPS tolerant cells. More recently, the group of Antonio Sica has shown that accumulation of p50 homodimers in the nucleus of Tumour Associated Macrophages results in defective expression of proinflammatory cytokines (TNFa, IL12) and reduced IL10 production, correlating with increased tumour growth. Moreover, p50 accumulation in the nucleus of macrophages is an essential event for promoting endotoxin tolerance and protumour polarized functions in these cells. Given the important role of p50 in controlling tolerance in innate immunity (macrophages), we wondered if p50 accumulation in Dendriic Cells could mediate their activation versus tolerant activity over adaptive immunity.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.