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the present work was devoted to develop an efficient synthetic process which requires cofactors. The enzymatic glucose 6phosphate (G6P) production from glucose was demonstrated as a model process. As cofactors, two new polymerbound adenine nucleotides (ATP and ADP) were synthesized using starburst polyamidoamine (PAMAM) dendrimers. Then, the kinetics of the reactions catalyzed by Bacillus stearothermophilus glucokinase (GK) and acetate kinase (AK) using these polymerbound cofactors were studied extensively. Finally, the production of G6P using the polymerbound ATP in a plug flowtype hollowfiber membrane reactor (PFMR) in a diffusion mode as well as a continuous stirred tanktype membrane reactor (CSTMR) in a filtration mode was investigated theoretically
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