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El descubrimiento de nuevos compuestos antifngicos es una necesidad urgente debido al incremento en las ltimas dcadas de pacientes inmunocomprometidos y a la ineficacia y toxicidad de las drogas existentes en uso clnico. El reino vegetal representa un enorme reservorio de molculas novedosas y particularmente la Argentina tiene una gran diversidad vegetal poco explorada en cuanto a su actividad antifngica. Utilizando un criterio etnofarmacolgico se seleccionaron 10 especies vegetales, de las cuales Polygonum acuminatum y P. persicaria resultaron las ms activas frente a un panel de hongos oportunistas y patognicos para el humano. Del fraccionamiento bioguiado de ambas especies se aislaron sesquiterpenos con esqueleto drimano y flavonoides del tipo flavanonas y chalconas como agentes antifngicos activos. Ambos tipos de compuestos fueron utilizados como marcadores qumicos con el fin de delimitar desde un punto de vista quimiotaxonmico a la seccin Persicaria del gnero Polygonum. Se prepararon derivados y anlogos de poligodial por semisntesis y por biotransformaciones, con los cuales se pudo realizar un interesante estudio de relacin estructuraactividad.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer,
birth defects, or other reproductive harm.
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