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PostTranscriptional Gene Regulation: Tools and Strategies for the Unraveling of PostTranscriptional Gene Regulatory Networks,Used
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To guarantee survival in a complex and everchanging environment, cells dispose of efficient and highly dynamic regulatory circuits that continuously interpret the genetic code in a contextdependent manner. RNA molecules play a central role in the flow of genetic information and are subject to particular scrutiny by a cell's regulatory machinery. They assemble into macromolecular complexes the socalled ribonucleoprotein particles which represent the functional units of posttranscriptional gene regulation and appear to be organized into highly intertwined, decentralized regulatory networks. Detailed insights into the underlying logic, logistics and organization principles of such networks should have broad implications for a large number of scientific and technological disciplines, including medicine, computer sciences and even (socio)economics. This book reviews the available literature and experimental techniques of this exciting field. It explains and further develops concepts and it presents strategies and tools for the identification of combinatorial control motifs, a fundamental buildingblock of posttranscriptional gene regulatory networks.
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