Probleme Der Cellulren Autophagie: Morphologische, Enzymcytochemische Und Quantitative Untersuchungen An Normalen Und Alterierte

Probleme Der Cellulren Autophagie: Morphologische, Enzymcytochemische Und Quantitative Untersuchungen An Normalen Und Alterierte

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Als cellulre Autophagie bezeichnet man einen Vorgang, bei dem innerhalb einer Zelle umschriebene Portionen des Cytoplasmas durch Membranen abge grenzt und damit in ein eigenes Kompartiment verlagert werden, in welchem dann das segregierte Material intracellulr verdaut, also in kleinere Einheiten aufgespalten wird. Der Terminus Autophagie wurde auf der cellulren Ebene erstmals von Brachet (1961) im Zusammenhang mit Stoffwechselumstellungen bei enucleier ten Amben verwandt. Von morphologischen Befunden ausgehend hatte aber schon vorher Altmann (1956) die Konzeption entwickelt, da Anteile des Cyto plasmas unter den Erscheinungen der umschriebenen Coagulation ausgegliedert und abgebaut werden knnen. Elektronenmikroskopische Untersuchungen (Hru ban et a1., 1962; Ashford u. Porter, 1962) und die Integration solcher Phno mene in das Lysosomenkonzept (Novikoff u. Essner, 1962; de Duve, 1963a, b; Ericsson et a1., 1965; de Duve u. Wattiaux, 1966) haben diese Vorstellung besttigt und eine Flle von Keimtnissen zutage gefrdert, die zuletzt von Ericsson (1969c) zusammenfassend dargestellt worden sind.

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We provide a 2-year limited warranty, from the date of purchase for all our products.

If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.

This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).

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