Title
ProteinInteraktionsanalyse der Tumorassoziierten Tyrosinkinase cKit: Zur Identifizierung neuer molekularer Wirkstoffziele fr ,Used
Delivery time: 8-12 business days (International)
Gastrointestinale Stromatumore (GIST) zhlen zu den hufigsten mesenchymalen Tumoren des Verdauungstraktes. Charakteristisch fr GIST sind aktivierende Mutationen in der Rezeptortyrosinkinase cKit. Der TyrosinkinaseInhibitor Imatinib ist Medikament erster Wahl zur Behandlung von GIST. Problematisch bei der ImatinibTherapie ist die hufig auftretende Resistenz. Da die Zweitlinientherapien nur mig erfolgreich sind wird nach neuen Wirkstoffzielen gesucht. Zur Identifizierung neuer und Charakterisierung bereits bekannter Wirkstoffziele fhrte die Autorin Jutta Panke vergleichende ProteinProteinInteraktionsanalysen mit GISTassoziierten cKit Mutanten und dem cKit Wildtyp durch. Dazu etablierte sie geeignete biochemische Methoden und identifizierte u.a. das Chaperon Hsp90 und dessen Cochaperon Cdc37 als Interaktionspartner von GISTassoziierten cKit Mutanten. Dieses Buch richtet sich an Mediziner, Biochemiker und Biologen, die sich fr molekulare Aspekte der Tumorbiologie und ProteinProtein Interaktionen interessieren.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.