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Quantifying cellECM adhesion by single cell force spectroscopy,Used
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Integrinmediated adhesive interactions of cells with the extracellular matrix (ECM) regulate important cellular functions and play a critical role in disease. Therefore, studying the mechanisms underlying integrinbinding and regulation is of great interest. In the presented work three respective biological questions have been addressed using Atomic Force Microscopy based Single Cell Force Spectroscopy (AFMSCFS). The work is split into six chapters. The first chapter provides an introduction into cellECM interactions. Thereafter different adhesion assays are compared and contrasted, and the theoretical BellEvans model is discussed. In chapter four, alpha2beta1integrin mediated cell adhesion to collagen I is quantified. Thereafter the effects of the exposure of cryptic integrin binding sites within collagen I on preosteoblasts are analysed. At last, the role of BCR/ABL in modulating myeloid progenitor cell adhesion to stromal cells and ECMcoated substrates is studied. Taken together, the work demonstrates that AFMSCFS is a versatile tool that permits monitoring of cell adhesion from singlemolecule recognition events to the formation of more complex adhesion sites.
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