Title
Recent Advances in Chordoma: Molecular Analysis and Identification of Therapeutic Targets,Used
Delivery time: 8-12 business days (International)
Chordoma is a rare malignant bone tumour, showing notochordal differentiation and occurs in the axial skeleton. Brachyury, a molecule involved in notochordal development, is a highly specific and sensitive marker for chordoma. It is hypothesised that brachyury or genes involved in its activation are implicated in the pathogenesis of chordoma. As there is no effective drug therapy for chordoma, the aim was to identify genetic events involved in chordoma pathogenesis with a view to identifying potential therapeutic targets. PI3K/AKT/TSC/mTOR pathway was found activated in 65% of chordomas, thereby providing a rationale for testing mTOR inhibitors for the treatment of selected cases. The fibroblastic growth factor receptor pathway was activated in more than 90% of the analysed cases. Nearly half of the cases showed chromosomal abnormalities involving the brachyury locus. Knockdown of brachyury gene was achieved, for the first time, in the UCH1 chordoma cell line using shRNA and resulted in premature cell senescence. EGFR copy number gain was detected by FISH in 45% of chordomas. The EGFR inhibitor, tyrphostin (AG1478) significantly inhibited growth of the chordoma cell line.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.