Title
Receptor polymorphisms and nonclassical bacterial immune stimuli: Variants of the human TLR4 and of the bacterial surface molec,Used
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The courses of infections, ranging from subclinical to lethal diseases, are determined by numerous variables of the host defence and of the nature of the pathogens. Genetic polymorphisms of both regulatory promoter and coding sequences are increasingly linked with disease susceptibility and outcome. The first part of this study is attributed to a variant of one of the human pattern recognition receptors, which constitute key elements for the initiation of an innate immune response. We elucidate the effects of the human heterozygous TLR4 Asp(299)Gly polymorphism on cytokine release and examine whether they play a role in Crohn's Disease. The focus of the second part is the functional analysis of nonclassical bacterial surface components, which are crucial for the initiation of immune defence mechanisms and which also determine the extent of inflammatory reactions. Hereby we examine the endotoxic properties of special lipopolysaccharide and lipoteichoic acid variants. This work wants to contribute to the understanding of the consequences of molecular variations for hostpathogen interaction and immune defence.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
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