Title
Regulation CpGmethylierter Promotoren des EpsteinBarr Virus (EBV): Identifizierung von methylierungssensitiven BZLF1responsit,Used
Delivery time: 8-12 business days (International)
Das EpsteinBarr Virus (EBV) gilt als eines der erfolgreichsten Viren des Menschen und dient als in vitro Modell humaner Tumorviren und latenter Virusinfektionen. Die virale DNA liegt in latent infizierten Zellen in einer chromatinhnlichen Konfiguration vor und ist hochgradig methyliert. Die Methylierung am 5Kohlenstoffatom der Base Cytosin in CpGDinukleotiden ist in metazoen Organismen mit einer Reprimierung der Genexpression assoziiert und gilt als einer der bedeutendsten epigenetischen Regulationsmechanismen. Im Laufe einer stetigen Koevolution hat EBV diese zellulren, epigenetischen Mechanismen adaptiert und fr die Kontrolle und Regulation seines biphasischen Infektionszyklus genutzt. Die virale Infektionsstrategie basiert auf der CpGmethylierungsabhngigen Aktivierung der lytischen Phase, die Voraussetzung fr die Synthese infektiser Nachkommenviren ist. Auf molekularer Ebene ist dieses paradoxe Phnomen auf die bisher einzigartige Eigenschaft des viralen Transkriptionsfaktors BZLF1 zurckzufhren, der bevorzugt oder exklusiv an CpGmethylierte Erkennungsmotive in viralen lytischen Promotoren bindet und dadurch die lytische Phase einleitet.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.