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If you have any questions, you are always welcome to contact us. We'll get back to you as soon as possible, withing 24 hours on weekdays.
Customer service
All questions about your order, return and delivery must be sent to our customer service team by e-mail at yourstore@yourdomain.com
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If you are interested in selling our products, need more information about our brand or wish to make a collaboration, please contact us at press@yourdomain.com
During mitosis, the replicated genome is segregated into two daughter nuclei. The chromatin condenses into chromosomes followed by the breakdown of the whole nucleus. After sister chromatid segregation by the mitotic spindle, the nuclei reform in the daughter cells and cell division can be completed with cytokinesis. Chromatin needs to be segregated and repackaged into nuclei with high fidelity, since errors cause genomic instability that in turn may lead to cell death or, worse, development of cancer. Reformation of the nucleus late in mitosis needs a high degree of coordination with chromosome segregation and spindle disassembly, but also among the NE formation, nuclear pore complex assembly and chromatin decondensation; however, regulation of the process is still poorly understood. In vitro, nucleus formation requires Cdc48/p97, a hexameric ATPase implicated in membrane fusion and ubiquitindependent processes. However, the role and relevance of Cdc48/p97 in nucleus formation have remained controversial. Here we show that Cdc48/p97 stimulates nucleus reformation by inactivating the chromatinassociated kinase Aurora B.
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