Title
Regulation of fluidshear stress by mechanosensory primary cilia: Role of mechanosensory property of endothelial primary cilia i,Used
Delivery time: 8-12 business days (International)
The primary cilium is an important sensory organelle present in most mammalian cells. By virtue of its structure and location, the cilium acts as a sensor. It senses conditions in the extra cellular matrix and transduces these messages to cell interior, resulting in altered gene expression and protein synthesis. Dysfunctional cilia result in a variety of diseases, collectively known as ciliopathies. Our current studies have a twofold aim. First, we show cilia length and functions are regulated by distinct, yet complex intertwined signaling pathways. Second, we show that dysfunctional dopamine receptors are related to hypertension observed in polycystic kidney disease (PKD). In addition to cystic kidneys, PKD is characterized by cardiovascular irregularities, including hypertension. Mouse vascular endothelia exhibit dopamine receptor5 (DR5) colocalized to primary cilia in cultured cells and mouse arteries invivo. DR5 plays very important role in ciliary length and function. Chemosensory function of cilia alters mechanosensory function through changes in sensitivity to fluidshear stress. We propose activated ciliary DR5 has functional mechanosensory role in endothelial cells.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.