Title
Regulation of Smoothened activity by Patched and lipoprotein lipids: Insights into the mechanism of inhibition,Used
Sold by Ergodebooks, an authorized reseller.
Returns accepted within 30 days | support@ergodebooks.com
Shipping Information
- Free Standard Shipping — United States only
- Processing Time: 1–3 business days
- Estimated Delivery: 3–5 business days after dispatch
- Double-boxed, fully insured & discreetly packaged
- Tracking number sent via email once dispatched
- Orders over $250 require signature upon delivery. Taxes calculated at checkout.
Returns & Refund
Returns accepted within 30 days of delivery.
Damaged or Defective Item
Free return shipping + replacement or full refund
Wrong Item Received
Free return shipping + replacement or full refund
Change of Mind
Return shipping at customer's expense · 25% restocking fee applies
Payment Option
Hedgehog is a morphogen that is carried on lipoproteins and that regulates patterning and proliferation. Hyperactivity of Hedgehog signaling causes numerous forms of cancer. Hedgehog acts via relieving repression of Smoothened by Patched the mechanism of this repression has been unclear. The structural homology of Patched with bacterial transmembrane transporters suggests that Patched might regulate lipid trafficking to repress Smoothened. However, no endogenous lipid regulators of Smoothened have yet been identified, nor has it ever been shown that Patched actually controls lipid trafficking. This work shows that, in Drosophila melanogaster, Patched regulates Smoothened trafficking from Patchedpositive endosomes. Furthermore, it demonstrates that Patched recruits internalized lipoproteins to these endosomes, thereby regulating the efflux of specific lipoproteinderived lipids from this compartment and utilizing these lipids to repress Smoothened. We propose that Patched normally promotes Smoothened degradation and inhibits its activity by utilizing a specific lipoproteinderived lipid. Further, we suggest that presence of Hedgehog on lipoproteins prevents their utilization.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.
For more information, please visit www.P65Warnings.ca.gov.