Title
Resistant Gram Negative Infections: The Challenges Ahead,Used
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The treatment of gramnegative bacteremia is increasingly complicated by the occurrence of multidrug resistant gramnegative bacilli strains. Normally susceptible bacteria may become resistant to antimicrobial agents through mutation and selection or acquisition from other bacteria of genetic information that encodes resistance. Enterobacterial resistance to thirdgeneration cephalosporins is typically caused by production of extendedspectrum betalactamases . CTXMs are one of the means of antibiotic resistant marker transfer among members of Enterobacteriaceae. Continous surveillance will be necessary to monitor the evolution of extended spectrum betalactamases and to verify whether the CTXM type ESBLs will eventually prevail over the TEMtype ESBLs, which are still widespread, in some areas. The present work unveils the increasing role of the blaCTXM lactamases in antibiotic resistance and the significance of appropriate treatment for infections caused by coliforms. Further studies are needed, however, to determine whether antibiotic policies or other measures can halt or lower the level of horizontal transfer that occurs in a hospital or community.
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