Title
Role of AMP Kinase in Volume Control of Colonic Crypts: AMPactivated Kinase controls Regulatory Volume Increase of Colonic Cryp,Used
Delivery time: 8-12 business days (International)
The intestines are the primary site for nutrient, fluid and electrolyte absorption and secretion. Fluid and salt secretion in the colon are managed by a fine balanced system of transporting mechanisms. CFTR and NKCC1 are two cell transporters, which have been identified as key players for fluid and electrolyte transportation across the cells membranes. During transcellular movement of ions, a mechanism must be in place to prevent shifts in cell volume. The antiporter NHE1 is involved in volume control but its regulator was unknown, so far. The author Thilo Schenck reports how he and his team caused a rapid change in cell volume of colonic crypt cells by exposing them to an osmotic shock and how the resulting transmembranous movements of electrolytes were studied by high speed video imaging. By specifically modulating intracellular AMP Kinase and the cell transporters NHE1 and CFTR, their finetuned interaction in cell volume regulation was revealed. This book describes the role of AMP Kinase acting as a volume sensor, which regulates CFTR and NHE1 activity to maintain a constant cell volume. The author concludes that AMP Kinase is the upstream regulator of NHE1.
By changing our most important processes and
products, we have already made a big leap forward. This ranges from the
increased use of more sustainable fibers to the use of more
environmentally friendly printing processes to the development of
efficient waste management in our value chain.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.
For more information, please visit www.P65Warnings.ca.gov.
Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
Secure Payment
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.
Secure Payment
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.