Title
Role of Ceramide In The Inhibition of Rat Chemical Hepatocarcinogenesis: A messenger of cell death,Used
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Ceramide are family of lipid molecules. Ceramide consist of a Longchain or Sphingoid base linked to a fatty acid via an amide bond. Ceramide has emerged as a key regulator of a wide spectrum of biological processes such as cellular differentiation, proliferation, programmed cell death (PCD), and apoptosis of cells. Cell proliferation studies were carried out in chemically induced rat hepatocarcinogenesis. Immunostaining of PCNA, Ki67 and BrdU results revealed that, Group C rats showed a minimal PCNA expression, decrement in ki67 expression and Low BrdU labeling suggesting the suppressive potential of Ceramide. DNA Damage and DNA protein cross link results revealed that, length and width ratio of DNA masses and Tailed cells were better in group C than that of Group B. Chemopreventive effect of Ceramide in apoptosis, study indicates a significant increase in the apoptotic labeling index in the Group C compared to that of group B as documented by TUNEL assay. Histochemical and Histopathological results suggested that,liver weight,GGTPositive foci andtumor incidence were better in group C than Group B.Ceramides were shown a promising chemopreventive potential against hepaticcancer.
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⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.
For more information, please visit www.P65Warnings.ca.gov.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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