Title
Role of neuronal IGF1R signaling in Alzheimers disease: Involvement in development and progression,Used
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Brains from patients with AD reveal a markedly down regulaton of IGF1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF1R signaling in AD a neuronspecific IGF1R deficient mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with earlyonset AD. The offsprings of these mice were analysed. KaplanMeieranalysis after 60 weeks of observation revealed that nIGF1R knockout mice were protected against premature mortality of AD mice and showed reduced A accumulation. In addition A plaque burden in animals with neuronal IGF1R deletion was also reduced compared to AD animals. Taken together IGF1R mediated signals influence APP processing leading to reduced A accumulation and amyloid plaque burden. Thus, downregulation of IGF1R observed in brain of patients suffering from Alzheimers disease is most likely a compensatory phenomenon.
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This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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