Title
Structural basis of the Lcarnitine/?butyrobetaine transport in CaiT (German Edition),Used
Delivery time: 8-12 business days (International)
Specialized transport proteins in the lipid bilayer perform the translocation of solutes across biological membranes. The prokaryotic Lcarnitine/?butyrobetaine transporter CaiT is a member of the betaine/carnitine/choline transporter (BCCT) family. However, CaiT is an interesting exception within the BCCT family since the transporter functions as a Na+ and H+ independent antiporter, while most members of the BCCT family require either an additional sodium ion or a proton to transport substrates into the cell. The threedimensional Xray crystal structure of CaiT reveals two different substratebinding sites within the protein and provides insights into important residues that directly interact with the two substrates Lcarnitine and ?butyrobetaine and enable substrate binding and transport without the need of an additional cation. The comparison of two threedimension CaiT structures in two different states together with results obtained from functional studies allowed the formulation of a model for the allosterically regulated substrate/product antiport mechanism in CaiT, which is also very likely conserved in eukaryotic Lcarnitine transporters.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
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Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.