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The emerging life sciences (genomics, proteomics...) require to the modern timeofflight mass spectrometry (TOFMS) the capability to identify and quantify massive macromolecules with masses larger than 100 kDa. The detectors commonly used in TOFMS have both sensitive area of square centimeters for a good geometric efficiency and a subnanosecond response time for a small mass resolution. Anyway they suffer a serious loss in detection efficiency for masses above 4 kDa up to become completely insensitive for values of about 100 kDa, limiting the effectiveness of the TOFMS technique. Here, I show how an innovative class of detectors, superconducting stripline detectors (SSLDs), allows a mass independent detection efficiency and unprecedented performances respect to the other superconducting detectors, in terms of both subnanosecond response time and large coverage area, when revealing keV molecules. All the aspects concerning the fabrication technology of superconducting thin films and nanopatterning by electron beam lithography for the SSLDs realization as well their characterization in a TOFMS are treated in this book. This book is integrally extracted by my PhD thesis.
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