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The reaction of atoluenesulphonyl chloride with various readily available amino acids in basic medium afforded atoluenesulphonamides (1ak) which were amidated with diethyl amine to obtain new N,Ndiethylalkanamido sulphonamide derivatives (2ak). The electrophilic addition of ptoluenesulphonyl chloride with various amino acids' nitrogen gave ptolylsulphonamide derivatives (4ak) which upon further reaction with diethylamine afforded N,Ndiethylamido substituted sulphonamide moieties (5ak). Sulphonylation of the amino acids with benzenesulphonyl chloride yielded benzenesulphonamides (7ak) which were amidated to afford N,Ndiethylamido benzenesulphonamide derivatives, (8ak). The chemical structures were confirmed by elemental analysis and spectroscopic techniques which involved FTIR, Mass Spectra, 1H and 13CNMR. The antimicrobial properties of the synthesized sulphonamides (fifty five compounds) were determined on Staphylococcus aureus and Escherichia coli using agar diffusion method where (1a) was the most active compound against Staphylococcus aureus at MIC value of 1.8 g/mL while (2k) and (5j) were the most active on Escherichia coli at MIC of 12.5 g/mL.
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