Title
Taxonomy of drug activity in vivo: A case study with selective estrogen receptor modulators,Used
Delivery time: 8-12 business days (International)
For more than one century, the measure of drug structureactivity relationships has been based on mathematical equations describing the drug interaction with its biological receptor. This analysis fails to evaluate a critical part of a therapy that is the dynamic response of the organism to the pharmacological assault: this response occurs within an unpredictable time window. Therefore, by introducing the time dimension in the study of drug effects, we might increase our ability to predict the therapeutic efficacy of a given compound. Here, the spacetemporal activation of drug targets is proposed as a measure of drug efficacy. The validity of this theory is demonstrated using imaging technologies and a reporter mouse in which drug action can be measured noninvasively. As a practical example, the taxonomy of selective estrogen receptor modulators (subject of my PhD dissertation with Prof. Adriana Maggi) is discussed. We show that the spacetemporal analysis of a biological function leads to the taxonomy of structurallyrelated compounds. This methodology could facilitate the preclinical to clinical transition.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
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Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.