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The Calculation Of Genetic Risks: Worked Examples In Dna Diagnostics-new
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It Will Be The Basic Aim Of This Book,' Writes Peter J. Bridge, 'To Impart To The Reader The Fundamentals Of How We Start With Laboratory Results And End Up With Numbers Representing Genetic Risks.' This Practical Guide For Both Clinical And Research Geneticists Explains How To Calculate An Individual'S Genetic Risk Based On Information Available From Genetic Testing And From Family Pedigrees. Bridge Begins With The General Theory Of Estimating Genetic Risks, Then Progresses Through Familial And Isolated Cases, Both Simple And Complex. A Major Strength Of The Book Lies In The Wealth Of Worked Examples Provided Throughout The Text. The Disorders Are Selected To Be Widely Applicable Or Adaptable As Needed.New To This Edition Are Sections On Consanguinity, Multipoint Linkage Analysis, Nonparametric Methods, Homozygosity Mapping, And Physical Mapping. Also New Is A Chapter On Other Dnabased Calculations, Including Sections On Paternity, Zygosity, Family Reconstructions, And Quantification Of Mitochondrial Mutations.From Reviews Of The First Edition: 'To Use A Computer Package Intelligently And Safely, You Need To Have In Reserve The Ability To Do The Calculation By Hand, At Least Approximately, So As To Appreciate Which Factors Contribute To The Risk. And The Current Computer Packages Cannot Cope With Several Factors Which Can Crucially Affect The Final Risk, Such As Germinal Mosaicism Or The Risk Of Maternal Cell Contamination... Bridge'S Book Is Very Thorough. Every Combination Of Pedigree Structure And Marker Data Is Discussed, With Numerous Tables Showing The Result Of Systematically Varying One Or More Parameters.' Journal Of Medical Genetics'A Useful Reference Book.' American Journal Of Human Genetics
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- Q: How many pages are in this book? A: This book contains two hundred forty-eight pages. It provides an extensive exploration of genetic risk calculation.
- Q: What is the binding type of this book? A: The binding type is hardcover. This ensures durability and longevity, making it suitable for frequent use.
- Q: What are the dimensions of this book? A: The dimensions are six and a half inches in length, one and twenty-six hundredths inches in width, and nine and a half inches in height.
- Q: Who is the author of this book? A: The author is Dr. Peter J. Bridge, PhD. He provides expert insights into the complexities of genetic risk calculations.
- Q: What is the primary focus of this book? A: The primary focus is on calculating genetic risks based on laboratory results and family pedigrees. It serves as a practical guide for geneticists.
- Q: Is this book suitable for beginners? A: Yes, this book is suitable for both beginners and experienced geneticists. It starts with fundamental concepts and progresses to complex cases.
- Q: How do I apply the concepts learned in this book? A: You can apply the concepts by using the worked examples provided to calculate genetic risks in practical scenarios.
- Q: Is this book appropriate for academic use? A: Yes, this book is appropriate for academic use. It includes comprehensive information and examples useful for research and clinical practice.
- Q: What new topics are covered in this edition? A: This edition covers new topics such as consanguinity, multipoint linkage analysis, and nonparametric methods among others.
- Q: How do I store this book to maintain its condition? A: Store the book upright in a cool, dry place away from direct sunlight. This will help preserve its condition over time.
- Q: Can this book be used as a reference guide? A: Yes, this book serves as a useful reference guide for geneticists. It includes numerous tables and examples for quick reference.
- Q: What if I receive a damaged book? A: If you receive a damaged book, contact the seller for a return or exchange. Most sellers have policies to address such issues.
- Q: Is there a warranty for this book? A: Typically, there is no warranty for books. However, return policies may vary by seller.
- Q: What type of reader would benefit most from this book? A: Both clinical and research geneticists will benefit most from this book. It addresses a wide range of genetic risk scenarios.
- Q: How does this book compare to other genetics books? A: This book is unique due to its extensive worked examples and practical approach to genetic risk calculations, setting it apart from others.
- Q: Are there reviews available for this book? A: Yes, there are several reviews available highlighting its thoroughness and usefulness as a reference text for geneticists.