Title
The Calculation of Genetic Risks: Worked Examples in DNA Diagnostics,Used
Delivery time: 8-12 business days (International)
"It will be the basic aim of this book," writes Peter J. Bridge, "to impart to the reader the fundamentals of how we start with laboratory results and end up with numbers representing genetic risks." This practical guide for both clinical and research geneticists explains how to calculate an individual's genetic risk based on information available from genetic testing and from family pedigrees. Bridge begins with the general theory of estimating genetic risks, then progresses through familial and isolated cases, both simple and complex. A major strength of the book lies in the wealth of worked examples provided throughout the text. The disorders are selected to be widely applicable or adaptable as needed.New to this edition are sections on consanguinity, multipoint linkage analysis, nonparametric methods, homozygosity mapping, and physical mapping. Also new is a chapter on other DNAbased calculations, including sections on paternity, zygosity, family reconstructions, and quantification of mitochondrial mutations.From reviews of the first edition: "To use a computer package intelligently and safely, you need to have in reserve the ability to do the calculation by hand, at least approximately, so as to appreciate which factors contribute to the risk. And the current computer packages cannot cope with several factors which can crucially affect the final risk, such as germinal mosaicism or the risk of maternal cell contamination... Bridge's book is very thorough. Every combination of pedigree structure and marker data is discussed, with numerous tables showing the result of systematically varying one or more parameters." Journal of Medical Genetics"A useful reference book." American Journal of Human Genetics
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To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Frequently Asked Questions
- Q: What is the main focus of 'The Calculation of Genetic Risks'? A: The book primarily focuses on teaching readers how to calculate genetic risks based on laboratory results, genetic testing, and family pedigrees.
- Q: Who is the author of this book? A: The author is Dr. Peter J. Bridge, who holds a PhD and has expertise in genetics.
- Q: What edition of the book is available? A: This listing features the 2nd edition of the book, published on October 6, 1997.
- Q: What topics are covered in the new edition? A: The new edition includes topics such as consanguinity, multipoint linkage analysis, nonparametric methods, homozygosity mapping, physical mapping, and DNA-based calculations including paternity and zygosity.
- Q: How many pages does the book have? A: The book contains a total of 248 pages.
- Q: What type of binding does this book have? A: The book is bound in hardcover.
- Q: What condition is the book in? A: The book is listed as used but in good condition.
- Q: Who would benefit from reading this book? A: Both clinical and research geneticists would benefit from the practical guidance and worked examples provided in the book.
- Q: Does the book provide worked examples? A: Yes, a major strength of the book is its wealth of worked examples that illustrate the calculation of genetic risks.
- Q: Is this book suitable for beginners in genetics? A: While the book covers fundamental concepts, it is designed for readers with some background in genetics, making it more suitable for intermediate to advanced learners.