The Friedlnder Reaction: Mechanism, Synthetic Applications and Experimental Conditions,Used

The Friedlnder Reaction: Mechanism, Synthetic Applications and Experimental Conditions,Used

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SKU: DADAX3838379071
Brand: LAP Lambert Academic Publishing
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The heterocyclic quinoline ring system is the core structure of a number of natural and nonnatural synthetic molecules endowed with interesting biological activities, and or physical properties. Accordingly, a number of methodologies for the synthesis of quinolines have been developed. The Friedlnder reaction is still one of the most efficient and simplest methods. The Friedlnder reaction is the base or acid promoted condensation of an aromatic 2aminosubstituted carbonyl compound with a carbonyl derivative bearing a reactive alfamethylene group, followed by cyclodehydration. In this book, a deep and rigorous presentation of the state of art on this reaction is described. After a short introduction, the mechanism, scope of the reaction, the synthetic applications, other concurrent synthetic methods for the preparation of quinolines and the typical experimental conditions are shown. Next, the reader finds some selected experimental procedures, and a number of tables where all the examples reported in the current and significant literature from 1982 to 2009 are incorporated. The book ends with recent developments, conclusions and perspectives. 490 references have been included.

⚠️ WARNING (California Proposition 65):

This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.

For more information, please visit www.P65Warnings.ca.gov.

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