Title
The Human TCell Receptor Repertoire and Transplantation (Molecular Biology Intelligence Unit),Used
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these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the ahelical structures of the a and a 1 2 domains and a floor which is formed by 8 antiparallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these ahelices and 13plated sheets within the groove. More importantly, these analyses also revealed the presence of elec trondense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 810 amino acids long. High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of socalled pockets within the grooves of the MHC class I molecules. These pockets designated AF, exhibited allelespecificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain noncovalently associated with a 28 kD 13 chain. With the excep tion of the DR achain, all other MHC class II a and 13 chains are poly morphic.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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