Title
The immune phenotype of mice deficient for Ly49Q: Dysregulated hematopoiesis and pDC activation,Used
Sold by Ergodebooks, an authorized reseller.
Returns accepted within 30 days | support@ergodebooks.com
Shipping Information
- Free Standard Shipping — United States only
- Processing Time: 1–3 business days
- Estimated Delivery: 3–5 business days after dispatch
- Double-boxed, fully insured & discreetly packaged
- Tracking number sent via email once dispatched
- Orders over $250 require signature upon delivery. Taxes calculated at checkout.
Returns & Refund
Returns accepted within 30 days of delivery.
Damaged or Defective Item
Free return shipping + replacement or full refund
Wrong Item Received
Free return shipping + replacement or full refund
Change of Mind
Return shipping at customer's expense · 25% restocking fee applies
Payment Option
Plasmacytoid dendritic cells are members of the innate immune system and are particularly important in antiviral immunity since they are the most potent producers of type I interferons. This book describes the phenotype of knockout mice for Ly49Q, a cell surface receptor expressed on pDCs. In vivo, knockout mice with PGKNeomycin insertion control early murine cytomegalovirus infection better, but no difference could be detected in mice with recombined LoxP sites. Thus, we observed a differential immune response dependent on the gene knockout strategy. In mice with PGKNeomycin insertion, we found enhanced hematopoiesis of some populations of the myeloid lineage and lower activation of pDCs following treatment with particular Tolllike receptor ligands, which translates into diminished T cell stimulatory capacity. This suggests a role for Ly49Q in regulating hematopoiesis and pDC activation potential.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.
For more information, please visit www.P65Warnings.ca.gov.