Title
The Role of CLCA2 in Tumourigenesis: Functional Characterisation of CalciumActivated Chloride Channel 2 (CLCA2) in Human Tumour,Used
Delivery time: 8-12 business days (International)
Identification of novel tumourspecific genes and pathways is a key strategy to gain additional prognostic markers and to identify molecular targets for chemical and/or immunological therapy. The combination of subtractive cDNA libraries and cDNA microarrays lead to the identification of the human calciumactivated chloride channel 2 (CLCA2), a member of the family of calciumactivated cytoplasmic transmembrane chloride channel proteins. CLCA2 is highly expressed in lung squamous cell carcinoma. In the course of this PhDThesis a preferential overexpression of CLCA2 was shown in human squamous cell carcinomas (SCC) of different origins. CLCA2 was confirmed as a promising target in SCC tumourigenesis by in silico analysis of expression data, lossoffunction studies in SCC cell lines by siRNAmediated knockdown, preliminary IHC analyses, inducible expression in tumour cells in combination with a detailed mutational analysis, 3DIn vitro carcinoma assays in multicellular tumour spheroids, expression profiling studies on Affymetrix GeneChips, and by utilising a text and datamining program for identification of several interactionnetworks.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.