The Role Of FibronectinIII1 In The Regulation Of Inflammatory Pathway: A novel finding between fibronectin matrix remodeling an,Used

The Role Of FibronectinIII1 In The Regulation Of Inflammatory Pathway: A novel finding between fibronectin matrix remodeling an,Used

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This book provides potential novel targets for therapies of human cancer and inflammatory diseases. The studies in this book have revealed the cryptic activity within the FnIII1 module modulates the tissue inflammatory response and suggests that fibronectin (Fn) matrix remodeling can induce the expression of cytokines by stromal cells present in the tissue microenvironment, providing evidence for a previously unrecognized link between fibronectin matrix remodeling and the regulation of the innate immune system. These studies have dissected FnIII1c's effects on fibronectin matrix from its effects on the activation of intracellular signaling, elucidated the mechanism by which unfolding of fibronectin Type III1 domain regulates inflammatory response in tissue microenvironment and clarified how local mechanical properties within tissue microenvironment may protect tumor cells from therapeutic treatment.

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