The Serotonin Receptors (The Receptors),Used

The Serotonin Receptors (The Receptors),Used

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Serotonin (5HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent. Early research focused on the measurement of concentrations, synthesis, and metabolism of 5HT, and only recently has the focus shifted to characterization of 5HT receptors. Gaddum and Picarelli first sug gested in 1957 that the effect of 5HT in the guinea pig ileum is mediated by two pharmacologically distinguishable receptors; however, the possibility of dual5HT receptors was not explored systematically or successfully until the past decade. It is now clear that more, perhaps many more, subclasses of 5HT receptors exist. The purpose of this book is to provide an uptodate report on 5HT receptors. This is a difficult task considering the astonishing speed at which research in this field is expanding. As the first of what we can expect to be a steady stream of monographs focusing on 5HT receptors, the book confirms that we are in an exciting time in the history of 5HT. For those of us who have been work ing on 5HT for many years, our dream of equal progress and recognition with the more extensively studied catecholamines is finally being realized. We now have a Serotonin Club that held its first international scientific meeting in 1987, and several more international meetings are in the planning stages.

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