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DNA computation has emerged in the last ten years as an exciting new search ?eld at the intersection (and, some would say, frontiers) of computer science,biology,engineering,andmathematics.AlthoughanticipatedbyFe man as long ago as the 1950s [59], the notion of performing computations at a molecular level was only realized in 1994, with Adlemans seminal work [3] on computing with DNA. Since then the ?eld has blossomed rapidly, with signi?cant theoretical and experimental results being reported regularly. Several books [120, 39] have described various aspects of DNA compu tion, but this is, to the authors best knowledge, the ?rst to bring together descriptions of both theoreticaland experimentalresults.The targetaudience is intentionally broad, including students as well as experienced researchers. We expect that users of the book will have some background in either c puter science, mathematics, engineering, or the life sciences. The intention is that this book be used as a tutorial guide for newcomers to the ?eld as well as a reference text for people already working in this fascinating area. To this end, we include two selfcontained tutorial chapters (1 and 2), which convey only those aspects of computer science and biology that are required to understand the subsequent material.
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