Title
Topical absorption and toxicity studies of hydrocarbons in skin: Methods and protocols for investigation of jet fuel induced der,Used
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Dermatitis is a major health concern associated with jet fuel exposures. The initial study addressed the possible mechanism for additive interactions on hydrocarbon disposition in synthetic and biological membranes. The remaining studies focused on neat hydrocarbon absorption and toxicity in pig skin. A dose related increase in percutaneous absorption of aromatic hydrocarbons was observed. This finding focuses attention to occupational settings where workers are repeatedly exposed to fuels. To assess the effects of jet fuel preexposure on subsequent hydrocarbon dermal absorption, pigs were exposed to JP8 soaked cotton with 4 repeated daily applications to mimic the occupational scenario. There was a 23 and 34 fold increase in absorption of short chain aliphatic and most of the aromatic hydrocarbons through 1 and 4day JP8 preexposed skin, respectively. Stratum corneum studies with FTIR spectroscopy suggested that lipid extraction might be the primary mechanism for this increase in hydrocarbon absorption. Finally, in vivo studies with the individual fuel hydrocarbons were conducted to identify the causative agents in fuel induced skin irritation.
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