Title
Translesion DNA Polymerases: Targeting Translesion DNA Synthesis in the Context of Cancer Therapy,Used
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While investigating the involvement of REV3, the catalytic subunit of TLS Polymerase zeta (Pol ?) in the development of chemotherapy resistance, it was found that inhibition of REV3 expression per se suppresses colony formation of cancer cells whereas normal cells were less affected. It was confirmed that inhibition of REV3 in various cancer cell lines leads to a growth inhibition, due to accumulation of persistent DNA damage, subsequently leading to the activation of the ATMdependent DNA damage response (DDR) cascade. Inhibition of REV3 in p53proficient cancer cells results in a G1arrest and senescence. In contrast, the inhibition of REV3 in p53deficient or p53knockout cancer cells results in a growth inhibition and a G2/Marrest whereas a small fraction of the p53deficient or p53knockout cancer cells can overcome the G2/Marrest, which results in mitotic slippage and aneuploidy. It is shown for the first time that inhibition of a TLS Pol confers synthetic sickness/lethality specifically in cancer cells. The inhibition REV3 per se suppresses cancer cell growth whereas normal cells are less affected, thus identifying REV3 as a potential target for a cancerspecific therapy.
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Shipping & Returns
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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