Transplantatsiya mezenkhimnykh stvolovykh kletok pri travme golovnogo mozga: Vliyanie transplantatsii mezenkhimnykh stvolovykh k,Used

Transplantatsiya mezenkhimnykh stvolovykh kletok pri travme golovnogo mozga: Vliyanie transplantatsii mezenkhimnykh stvolovykh k,Used

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Brand: LAP Lambert Academic Publishing
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Nastoyashchaya rabota otnositsya k chislu fundamental'nykh issledovaniy v oblasti neyromorfologii. Tsel' raboty izuchenie vliyaniya razlichnykh metodov transplantatsii singennykh mezenkhimnykh stvolovykh kletok (MSK) na golovnoy mozg pri ego obshirnoy mekhanicheskoy travme, zatragivayushchey neokorteks i yadernye struktury. Pokazano, chto MSK okazyvayut neyroprotektornoe deystvie na piriformnuyu koru kontralateral'nogo polushariya i stimuliruyut neoangiogenez v zone povrezhdeniya mozga, chto, po vsey vidimosti, sposobstvuet uluchsheniyu trofiki tkani. Zaregistrirovana razlichnaya lokalizatsiya MSK v mozge pri raznykh sposobakh transplantatsii. Prodemonstrirovano uskorenie protsessov ochishcheniya zony povrezhdeniya ot nekroticheskikh mass i kletochnogo detrita posle naneseniya travmy i vvedeniya MSK vnutrivenno i v mozg zhivotnogo. Prodemonstrirovano formirovanie v bazal'nykh strukturakh mozga anomal'nykh kletochnykh skopleniy, soderzhashchikh fibroblastopodobnye kletki i kollagenovye volokna, i obrazovanie anomal'no rasshirennykh kapillyarov v razlichnykh strukturakh mozga posle transplantatsii MSK v mozg. Pri vnutrivennom vvedenii MSK pokazano umen'shenie kolichestva vnutrimozgovykh struktur, razrushennykh v rezul'tate formirovaniya travmaticheskoy polosti.

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