Title
Virus and RNA Silencing: Polerovirus P0 and its mechanism of action in host plant,Used
Sold by Ergodebooks, an authorized reseller.
Returns accepted within 30 days | support@ergodebooks.com
Shipping Information
- Free Standard Shipping — United States only
- Processing Time: 1–3 business days
- Estimated Delivery: 3–5 business days after dispatch
- Double-boxed, fully insured & discreetly packaged
- Tracking number sent via email once dispatched
- Orders over $250 require signature upon delivery. Taxes calculated at checkout.
Returns & Refund
Returns accepted within 30 days of delivery.
Damaged or Defective Item
Free return shipping + replacement or full refund
Wrong Item Received
Free return shipping + replacement or full refund
Change of Mind
Return shipping at customer's expense · 25% restocking fee applies
Payment Option
The poleroviruses are an agronomically important genus of plant viruses which can infect a wide range of hosts. Their genome is a singlestranded plussense RNA. The 5terminal ORF encodes the 29 kDa protein P0, a strong suppressor of Post Transcriptional Gene Silencing (PTGS), an important antiviral defense system in plants. I have investigated the mechanism of action of P0 in suppression of RNA silencing. Our data support a model in which P0 acts as an Fbox protein, recruiting the posttranslational modification system to overcome the posttranscriptional gene silencing system. In this model P0 interacts with SKP to constitute a SCFP0 complex which presumably addresses ARGONAUTE1 that is the slicer protein in the RNAinduced silencing complex (RISC), for ubiquitination and degradation by 26S proteasome. This would be the first example of a suppressor of RNA silencing that acts in an SCF complex to promote degradation of an essential component of the silencing pathway, thereby, inhibiting the plant antiviral defense.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.
For more information, please visit www.P65Warnings.ca.gov.