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The poleroviruses are an agronomically important genus of plant viruses which can infect a wide range of hosts. Their genome is a singlestranded plussense RNA. The 5terminal ORF encodes the 29 kDa protein P0, a strong suppressor of Post Transcriptional Gene Silencing (PTGS), an important antiviral defense system in plants. I have investigated the mechanism of action of P0 in suppression of RNA silencing. Our data support a model in which P0 acts as an Fbox protein, recruiting the posttranslational modification system to overcome the posttranscriptional gene silencing system. In this model P0 interacts with SKP to constitute a SCFP0 complex which presumably addresses ARGONAUTE1 that is the slicer protein in the RNAinduced silencing complex (RISC), for ubiquitination and degradation by 26S proteasome. This would be the first example of a suppressor of RNA silencing that acts in an SCF complex to promote degradation of an essential component of the silencing pathway, thereby, inhibiting the plant antiviral defense.
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