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Help
If you have any questions, you are always welcome to contact us. We'll get back to you as soon as possible, withing 24 hours on weekdays.
Customer service
All questions about your order, return and delivery must be sent to our customer service team by e-mail at yourstore@yourdomain.com
Sale & Press
If you are interested in selling our products, need more information about our brand or wish to make a collaboration, please contact us at press@yourdomain.com
Salitsilaty (v t.ch. aspirin) otnosyatsya k gruppe nesteroidnykh protivovospalitel'nykh sredstv. Pobochnye effekty salitsilatov mozhno razdelit' na tri gruppy: 1) Effekty, voznikayushchie v rezul'tate snizheniya biosinteza prostaglandinov: ul'tserogennoe deystvie na zheludochnokishechnyy trakt; povrezhdenie pochek; povyshenie arterial'nogo davleniya; 2) Toksicheskie effekty: gepato i gematoksichnost'; 3) allergicheskie reaktsii. V to vremya kak mekhanizmy vozniknoveniya pobochnykh effektov pervoy i tret'ey grupp dostatochno khorosho izucheny, izmeneniya v kletke, razvivayushchiesya pri toksicheskikh vozdeystviyakh, v chastnosti, na pechen', ostayutsya ne do kontsa vyyasnennymi. Kak pravilo, lekarstva imeyut mnozhestvennye effekty na vnutrikletochnyy metabolizm. Problema vyyavleniya glavnykh i vtorostepennykh mekhanizmov toksicheskogo deystviya lekarstv ne mozhet byt' reshena tol'ko eksperimental'no, t. k. analiz razlichnykh vliyaniy trebuet ikh izbiratel'nogo vyklyucheniya, chto obychno nevozmozhno sdelat' v eksperimente. S pomoshch'yu predstavlennoy modeli segmenta tsikla Krebsa mitokhondrii, funktsioniruyushchey pri povyshennom energopotreblenii, izucheny effekty salitsilata na tsentral'nyy metabolizm gepatotsita.
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