Vliyanie salitsilata na tsikl Krebsa mitokhondrii: Kineticheskaya model' (Russian Edition),Used

Vliyanie salitsilata na tsikl Krebsa mitokhondrii: Kineticheskaya model' (Russian Edition),Used

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Salitsilaty (v t.ch. aspirin) otnosyatsya k gruppe nesteroidnykh protivovospalitel'nykh sredstv. Pobochnye effekty salitsilatov mozhno razdelit' na tri gruppy: 1) Effekty, voznikayushchie v rezul'tate snizheniya biosinteza prostaglandinov: ul'tserogennoe deystvie na zheludochnokishechnyy trakt; povrezhdenie pochek; povyshenie arterial'nogo davleniya; 2) Toksicheskie effekty: gepato i gematoksichnost'; 3) allergicheskie reaktsii. V to vremya kak mekhanizmy vozniknoveniya pobochnykh effektov pervoy i tret'ey grupp dostatochno khorosho izucheny, izmeneniya v kletke, razvivayushchiesya pri toksicheskikh vozdeystviyakh, v chastnosti, na pechen', ostayutsya ne do kontsa vyyasnennymi. Kak pravilo, lekarstva imeyut mnozhestvennye effekty na vnutrikletochnyy metabolizm. Problema vyyavleniya glavnykh i vtorostepennykh mekhanizmov toksicheskogo deystviya lekarstv ne mozhet byt' reshena tol'ko eksperimental'no, t. k. analiz razlichnykh vliyaniy trebuet ikh izbiratel'nogo vyklyucheniya, chto obychno nevozmozhno sdelat' v eksperimente. S pomoshch'yu predstavlennoy modeli segmenta tsikla Krebsa mitokhondrii, funktsioniruyushchey pri povyshennom energopotreblenii, izucheny effekty salitsilata na tsentral'nyy metabolizm gepatotsita.

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